CHEMOTHERAPY AND GUT MICROFLORA: A LITERATURE REVIEW ON THE EFFECTS IN MULTIPLE MYELOMA TREATMENT
Keywords:
Chemotherapy, Gut Microbiota, DysbiosisAbstract
In this review, we looked at studies from 2018 to 2024 to understand how chemotherapy affects the gut microbiome in MM patients. We found that certain drugs, like melphalan and bortezomib, can significantly change the gut microbiome, making patients more likely to get infections or experience side effects. We also explored how dysbiosis can impact treatment outcomes and the cancer environment. Based on the articles we studied and discussed ways to prevent or fix these problems. For example, probiotics, special diets, and fecal microbiota transplantation (FMT) show promise in restoring a healthy gut microbiome and improving treatment results. This review highlights the importance of considering the gut microbiome in MM treatment and suggests that personalized approaches could help patients feel better and respond better to therapy. By understanding the connection between chemotherapy and the gut microbiome, we can work toward better care for MM patients
References
Yang, Q., Wei, Y., Zhu, Y., Guo, J.,
Zhang, J., He, Y., Li, X., Liu, J., & Zhou, W.
(2023). The Interaction between Gut Microbiota
and Host Amino Acids Metabolism in Multiple
Myeloma. Cancers, 15(7), 1942.
https://doi.org/10.3390/cancers15071942
Zhang, C.-Y., Zhang, D., Sun, W.-R.,
Tang, H.-L., Tian, B., Hu, L.-H., Hu, W.-Y., Gao,
Y.-Y., Li, M.-Y., Xiao, W.-T., Gao, S., & Gao, G.-
X. (2024). Causal associations between the gut
microbiota and multiple myeloma: a twosample Mendelian randomization study.
Frontiers in Nutrition, 11, 14001114.
https://doi.org/10.3389/fnut.2024.1400116
Jian, X., Zhu, Y., Ouyang, J., Wang, Y.,
Lei, Q., Xia, J., Guan, Y., Zhang, J., Guo, J., He,
Y., & Zhou, W. (2020). Alterations of gut
microbiome accelerate multiple myeloma
progression by increasing the relative
abundances of nitrogen-recycling bacteria.
Microbiome, 8(1), 74.
https://doi.org/10.1186/s40168-020-00854-5
Calcinotto, A., Brevi, A., Chesi, M.,
Ferrarese, R., Garcia Perez, L., Grioni, M.,
Kumar, S., Garbitt, V. M., Sharik, M. E.,
Henderson, K. J., Tonon, G., & Ghobrial, I. M.
(2018). Microbiota-driven interleukin-17-
producing cells and eosinophils synergize to
accelerate multiple myeloma progression.
Nature Communications, 9(1), 4832.
https://doi.org/10.1038/s41467-018-07305-8
Pianko, M. J., Devlin, S. M., Littmann,
E. R., Chansakul, A., Mastery, D., Salcedo, M.,
Fontana, E., Ling, L., Tavitian, E., Slingerland,
J. B., & Peled, J. U. (2019). Minimal residual
disease negativity in multiple myeloma is
associated with intestinal microbiota
composition. Blood Advances, 3(14), 2040–
https://doi.org/10.1182/bloodadvances.20190
D’Angelo C, Sudakaran S,
Asimakopoulos F, et al. Perturbation of the Gut
Microbiome and Association with Outcomes
Following Autologous Stem Cell Transplantation
in Patients with Multiple Myeloma. Leuk
Lymphoma. 2023;64(1):87–97.
https://doi.org/10.1080/10428194.2022.21314
Gallagher K, et al. Probiotics in
Hematopoietic Stem Cell Transplantation: A
Review of the Literature. Blood Advances.
;6(12):3924-3935.
Zhou L, et al. The Impact of Bortezomib
on Gut Microbiota in Multiple Myeloma
Patients. Frontiers in Immunology.
;12:678123.
Jasinski M, Bilinski J, Basak GW. The
Role of the Gut Microbiome in Pathogenesis, Biology, and Treatment of Plasma Cell
Dyscrasias. Frontiers in Oncology.
;11:741376.
https://doi.org/10.3389/fonc.2021.741376
Baruch EN, Youngster I, Ben-Betzalel
G, et al. Fecal Microbiota Transplant Promotes
Response in Immunotherapy-Refractory
Melanoma Patients. Science.
;371(6529):602–609.
https://doi.org/10.1126/science.abb5920.
Alkharabsheh O, Sidiqi MH, Aljama MA,
Gertz MA, Frankel AE. The Human Microbiota in
Multiple Myeloma and Proteasome Inhibitors.
Acta Haematologica. 2020;143:118–123.
https://doi.org/10.1159/000500976.
Kanellos PT, Baxevanis GK, Tentolouris
A, Gavriatopoulou M, Ntanasis-Stathopoulos I.
The Role of Nutrition and Gut Microbiome in the
Progression of Multiple Myeloma and Its
Precursor Disease. Frontiers in Oncology.
;14:1461128.
https://doi.org/10.3389/fonc.2024.1461128.
Henig I, Yehudai-Ofir D, Zuckerman T.
The clinical role of the gut microbiome and fecal
microbiota transplantation in allogeneic stem
cell transplantation. Haematologica
;106(4):933-946;
https://doi.org/10.3324/haematol.2020.24739
J.A. Kholmatov1,3, Sharodiya Das2,
Sh.B. Kakhkharova1,3, Shuaib Alam4. (2025).
EARLY DIAGNOSTICS OF ONCOLOGICAL
DISEASES IN THE EXAMPLE OF MULTIPLE
MYELOMA: MODERN TECHNOLOGIES [Data
set]. Zenodo.
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